Insulin Receptor Alpha Antibody MBS4380049 from MyBioSource.com

Product Specs
ItemInsulin Receptor Alpha Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS4380049
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsImmunohistochemistry (IHC) Formalin
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman. Others not known
TargetInsulin Receptor Alpha
IsotypeIgG
Molecular Weight135kDa
CloneINSR/2277R
HostRabbit
ImmunogenThe insulin receptor (IR) is a heterodimeric protein complex that has an intracellular subunit and an extracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells
NCBI Full Gene Nameinsulin receptor
NCBI Gene AliasesCD220, HHF5
ClonalityMonoclonal